| 9/1/2016 | Defiance | 0 | at | Baldwin-Wallace (3-7) | 42 | at OAC | ||
| 9/10/2016 | Hope (7-3) | 6 | at | Defiance | 18 | MIAA | ||
| 9/17/2016 | Franklin (8-2,7-1) | 41 | at | Defiance | 6 | |||
| 9/24/2016 | Rose-Hulman (8-3,7-1) | 23 | at | Defiance | 15 | |||
| 10/1/2016 | Defiance | 59 | at | Earlham (0-10,0-8) | 28 | |||
| 10/8/2016 | Defiance | 20 | at | Manchester (2-8,2-6) | 14 | |||
| 10/15/2016 | Anderson (1-9,1-7) | 13 | at | Defiance | 20 | |||
| 10/29/2016 | Defiance | 20 | at | Hanover (4-6,4-4) | 27 | |||
| 11/5/2016 | Mt St Joseph (6-4,6-2) | 21 | at | Defiance | 20 | |||
| 11/12/2016 | Defiance | 28 | at | Bluffton (7-3,5-3) | 20 |
| vs Defiance | vs Other Opponents | Defiance compared to OOs | |
| Record: | 5-5 | 41-50 | |
| Points Scored: | 23.50 | 27.35 | 3.85 |
| Points Allowed: | 20.60 | 29.75 | -9.15 |
| Margin: | 2.90 | -2.40 | -5.30 |
| Total Points: | 44.10 | 57.10 | -13.00 |