| 9/3/2016 | Panhandle State | 21 | at | Sam Houston (12-1) | 59 | at SLC | ||
| 9/10/2016 | Panhandle State | 20 | at | Ark Pine Bluff (1-10) | 16 | at SWAC | ||
| 9/17/2016 | Panhandle State | 21 | at | Western New Mexico (3-8) | 44 | at RMAC | ||
| 9/25/2016 | Panhandle State | 24 | at | Midwestern State (8-3,6-2) | 42 | |||
| 10/1/2016 | Texas A&M-Commerce (10-2,7-1) | 35 | at | Panhandle State | 13 | |||
| 10/8/2016 | Panhandle State | 9 | at | Angelo State (5-6,4-4) | 31 | |||
| 10/15/2016 | West Texas A&M (6-5,4-4) | 42 | at | Panhandle State | 14 | |||
| 10/22/2016 | Panhandle State | 54 | at | Texas-Permian Basin (2-9,0-8) | 44 | |||
| 10/29/2016 | Tarleton State (5-6,4-4) | 45 | at | Panhandle State | 26 | |||
| 11/5/2016 | Panhandle State | 10 | at | Eastern New Mexico (7-5,5-3) | 53 | |||
| 11/12/2016 | Texas A&M-Kingsville (9-3,5-3) | 53 | at | Panhandle State | 39 |
| vs Panhandle State | vs Other Opponents | Panhandle State compared to OOs | |
| Record: | 9-2 | 59-56 | |
| Points Scored: | 42.18 | 30.08 | -12.10 |
| Points Allowed: | 22.82 | 30.85 | -8.03 |
| Margin: | 19.36 | -0.77 | -20.13 |
| Total Points: | 65.00 | 60.93 | 4.07 |