| 9/10/2016 | Nicholls State | 24 | at | Georgia (8-5) | 26 | at SEC | ||
| 9/17/2016 | Incarnate Word (3-8,3-6) | 28 | at | Nicholls State | 35 | |||
| 9/24/2016 | Nicholls State | 40 | at | South Alabama (6-7) | 41 | OT | at SBC | |
| 10/1/2016 | Nicholls State | 13 | at | McNeese State (6-5,5-4) | 38 | |||
| 10/8/2016 | Stephen F. Austin (5-6,4-5) | 28 | at | Nicholls State | 35 | 2OT | ||
| 10/15/2016 | Nicholls State | 33 | at | Houston Baptist (4-7,3-5) | 30 | 2OT | ||
| 10/22/2016 | Sam Houston (12-1,9-0) | 38 | at | Nicholls State | 21 | |||
| 10/29/2016 | Nicholls State | 31 | at | Northwestern State (1-10,0-9) | 14 | |||
| 11/3/2016 | Lamar (3-8,3-6) | 10 | at | Nicholls State | 35 | |||
| 11/12/2016 | Nicholls State | 24 | at | Central Arkansas (10-3,8-1) | 31 | |||
| 11/17/2016 | Southeastern Louisiana (7-4,7-2) | 44 | at | Nicholls State | 42 |
| vs Nicholls State | vs Other Opponents | Nicholls State compared to OOs | |
| Record: | 6-5 | 59-59 | |
| Points Scored: | 29.82 | 28.61 | -1.21 |
| Points Allowed: | 30.27 | 29.97 | 0.30 |
| Margin: | -0.45 | -1.36 | -0.91 |
| Total Points: | 60.09 | 58.58 | 1.51 |