| 9/1/2016 | East Stroudsburg | 49 | at | Brevard | 14 | PSAC | ||
| Humboldt State | 52 | at | Carson-Newman | 45 | GNWAC | |||
| Mars Hill | 7 | at | Samford | 77 | @ SoCon (1AA) | |||
| Virginia-Wise | 13 | at | Tusculum | 10 | 2OT | MtnE | ||
| 9/3/2016 | Virginia State | 34 | at | Lenoir-Rhyne | 9 | CIAA | ||
| Florida Tech | 42 | at | Newberry | 28 | GSC | |||
| Catawba | 3 | at | West Georgia | 23 | @ GSC | |||
| Johnson C Smith | 28 | at | Wingate | 38 | CIAA | |||
| 9/10/2016 | Winston-Salem State | 23 | at | Catawba | 17 | CIAA | ||
| Brevard | 14 | at | Emory & Henry | 28 | @ ODC (D3) | |||
| North Greenville | 45 | at | Lenoir-Rhyne | 0 | D2Ind | |||
| Shorter | 21 | at | Mars Hill | 28 | OT | GSC | ||
| Virginia Union | 22 | at | Newberry | 42 | CIAA | |||
| Carson-Newman | 48 | at | St Augustine's | 14 | @ CIAA | |||
| Tusculum | 10 | at | Virginia State | 24 | @ CIAA | |||
| Shaw | 7 | at | Wingate | 56 | CIAA | |||
| 9/17/2016 | Wingate | 34 | at | Brevard | 7 | |||
| Carson-Newman | 20 | at | Catawba | 40 | ||||
| Tusculum | 3 | at | Lenoir-Rhyne | 31 | ||||
| Mars Hill | 42 | at | Limestone | 39 | @ D2Ind | |||
| Newberry | 29 | at | North Greenville | 28 | @ D2Ind | |||
| 9/24/2016 | Apprentice | 7 | at | Brevard | 38 | D3Ind (D3) | ||
| Mars Hill | 27 | at | Carson-Newman | 52 | ||||
| Limestone | 31 | at | Lenoir-Rhyne | 13 | D2Ind | |||
| Newberry | 37 | at | Tusculum | 10 | ||||
| Catawba | 48 | at | Wingate | 26 | ||||
| 10/1/2016 | Lenoir-Rhyne | 20 | at | Carson-Newman | 17 | |||
| Wingate | 45 | at | Limestone | 26 | @ D2Ind | |||
| Catawba | 14 | at | Newberry | 35 | ||||
| Mars Hill | 21 | at | North Greenville | 56 | @ D2Ind | |||
| Brevard | 14 | at | Tusculum | 21 | ||||
| 10/8/2016 | Carson-Newman | 47 | at | Brevard | 0 | |||
| Limestone | 6 | at | Catawba | 0 | D2Ind | |||
| UNC Pembroke | 36 | at | Lenoir-Rhyne | 20 | D2Ind | |||
| Newberry | 35 | at | Mars Hill | 21 | ||||
| Tusculum | 0 | at | Wingate | 19 | ||||
| 10/15/2016 | Brevard | 17 | at | Limestone | 28 | @ D2Ind | ||
| Catawba | 33 | at | Mars Hill | 22 | ||||
| Carson-Newman | 19 | at | Newberry | 34 | ||||
| North Greenville | 31 | at | Tusculum | 7 | D2Ind | |||
| Lenoir-Rhyne | 6 | at | Wingate | 49 | ||||
| 10/22/2016 | Newberry | 34 | at | Brevard | 7 | |||
| Wingate | 29 | at | Carson-Newman | 16 | ||||
| Mars Hill | 49 | at | Lenoir-Rhyne | 0 | ||||
| Limestone | 13 | at | Tusculum | 34 | D2Ind | |||
| Catawba | 31 | at | UNC Pembroke | 41 | @ D2Ind | |||
| 10/29/2016 | Limestone | 25 | at | Carson-Newman | 39 | D2Ind | ||
| Brevard | 7 | at | Catawba | 42 | ||||
| Tusculum | 27 | at | Mars Hill | 28 | OT | |||
| Lenoir-Rhyne | 14 | at | Newberry | 53 | ||||
| Wingate | 30 | at | North Greenville | 34 | @ D2Ind | |||
| 11/5/2016 | Lenoir-Rhyne | 21 | at | Brevard | 14 | |||
| Tusculum | 38 | at | Catawba | 28 | ||||
| Newberry | 49 | at | Limestone | 7 | @ D2Ind | |||
| Carson-Newman | 24 | at | North Greenville | 34 | @ D2Ind | |||
| Mars Hill | 39 | at | Wingate | 42 | ||||
| 11/12/2016 | Catawba | 16 | at | Lenoir-Rhyne | 14 | |||
| Brevard | 6 | at | Mars Hill | 35 | ||||
| Wingate | 22 | at | Newberry | 27 | ||||
| Carson-Newman | 30 | at | Tusculum | 31 | OT | |||
| 11/19/2016 | Tuskegee | 35 | at | Newberry | 33 | SIAC |