| 9/1/2016 | West Alabama (7-4) | 23 | at | North Greenville | 24 | GSC | ||
| 9/10/2016 | North Greenville | 45 | at | Lenoir-Rhyne (3-8) | 0 | at SAC | ||
| 9/17/2016 | Newberry (10-2) | 29 | at | North Greenville | 28 | SAC | ||
| 9/24/2016 | North Greenville | 35 | at | UNC Pembroke (10-2,2-0) | 49 | |||
| 10/1/2016 | Mars Hill (5-6) | 21 | at | North Greenville | 56 | SAC | ||
| 10/6/2016 | North Greenville | 14 | at | The Citadel (10-2) | 38 | at SoCon | ||
| 10/15/2016 | North Greenville | 31 | at | Tusculum (4-7) | 7 | at SAC | ||
| 10/22/2016 | North Greenville | 21 | at | North Alabama (11-2) | 52 | at GSC | ||
| 10/29/2016 | Wingate (8-3) | 30 | at | North Greenville | 34 | SAC | ||
| 11/5/2016 | Carson-Newman (4-7) | 24 | at | North Greenville | 34 | SAC | ||
| 11/12/2016 | North Greenville | 37 | at | Limestone (5-6,0-1) | 0 | |||
| 11/19/2016 | North Greenville | 27 | at | Florida Tech (8-3) | 13 | at GSC | ||
| 11/26/2016 | Tuskegee (9-3) | 26 | at | North Greenville | 45 | SIAC | ||
| 12/3/2016 | North Greenville | 0 | at | North Alabama (11-2) | 38 | D2 Quarterfinal | at GSC |
| vs North Greenville | vs Other Opponents | North Greenville compared to OOs | |
| Record: | 5-9 | 98-48 | |
| Points Scored: | 25.00 | 30.84 | 5.84 |
| Points Allowed: | 30.79 | 22.72 | 8.07 |
| Margin: | -5.79 | 8.12 | 13.91 |
| Total Points: | 55.79 | 53.56 | 2.23 |