| 8/30/2012 | Southern Illinois | 28 | at | Eastern Illinois (7-5) | 49 | at OVC | ||
| 9/8/2012 | Southern Illinois | 14 | at | Miami-Ohio (4-8) | 30 | at MAC | ||
| 9/15/2012 | SE Missouri State (3-8) | 14 | at | Southern Illinois | 35 | OVC | ||
| 9/22/2012 | Southern Illinois | 14 | at | Missouri State (3-8,3-5) | 6 | |||
| 9/29/2012 | Indiana State (7-4,5-3) | 24 | at | Southern Illinois | 3 | |||
| 10/6/2012 | Southern Illinois | 17 | at | Illinois State (9-4,5-3) | 0 | |||
| 10/13/2012 | Northern Iowa (5-6,4-4) | 31 | at | Southern Illinois | 34 | |||
| 10/20/2012 | Southern Illinois | 38 | at | Youngstown State (7-4,4-4) | 21 | |||
| 10/27/2012 | Southern Illinois | 17 | at | North Dakota State (14-1,8-1) | 23 | |||
| 11/3/2012 | South Dakota State (9-4,6-3) | 16 | at | Southern Illinois | 12 | |||
| 11/17/2012 | Western Illinois (3-8,1-7) | 0 | at | Southern Illinois | 35 |
| vs Southern Illinois | vs Other Opponents | Southern Illinois compared to OOs | |
| Record: | 5-6 | 66-54 | |
| Points Scored: | 19.45 | 26.53 | 7.08 |
| Points Allowed: | 22.45 | 24.50 | -2.05 |
| Margin: | -3.00 | 2.03 | 5.03 |
| Total Points: | 41.90 | 51.03 | -9.13 |