| 9/1/2012 | South Dakota | 24 | at | Montana (5-6) | 35 | at BSky | ||
| 9/8/2012 | Colgate (8-4) | 21 | at | South Dakota | 31 | Pat | ||
| 9/22/2012 | South Dakota | 7 | at | Northwestern (10-3) | 38 | at B10 | ||
| 9/29/2012 | Illinois State (9-4,5-3) | 34 | at | South Dakota | 31 | |||
| 10/6/2012 | Western Illinois (3-8,1-7) | 24 | at | South Dakota | 17 | |||
| 10/13/2012 | South Dakota | 24 | at | Missouri State (3-8,3-5) | 27 | |||
| 10/20/2012 | North Dakota State (14-1,8-1) | 54 | vs | South Dakota | 0 | Sioux Falls SD | ||
| 10/27/2012 | South Dakota | 14 | at | Indiana State (7-4,5-3) | 45 | |||
| 11/3/2012 | South Dakota | 10 | at | Youngstown State (7-4,4-4) | 13 | |||
| 11/10/2012 | Northern Iowa (5-6,4-4) | 24 | at | South Dakota | 21 | |||
| 11/17/2012 | South Dakota | 8 | at | South Dakota State (9-4,6-3) | 31 |
| vs South Dakota | vs Other Opponents | South Dakota compared to OOs | |
| Record: | 10-1 | 70-51 | |
| Points Scored: | 31.45 | 27.13 | -4.32 |
| Points Allowed: | 17.00 | 22.71 | -5.71 |
| Margin: | 14.45 | 4.42 | -10.03 |
| Total Points: | 48.45 | 49.84 | -1.39 |