| 8/30/2012 | South Carolina | 17 | at | Vanderbilt (9-4,5-3) | 13 | |||
| 9/8/2012 | East Carolina (8-5) | 10 | at | South Carolina | 48 | CUSA | ||
| 9/15/2012 | UAB (3-9) | 6 | at | South Carolina | 49 | CUSA | ||
| 9/22/2012 | Missouri (5-7,2-6) | 10 | at | South Carolina | 31 | |||
| 9/29/2012 | South Carolina | 38 | at | Kentucky (2-10,0-8) | 17 | |||
| 10/6/2012 | Georgia (12-2,7-2) | 7 | at | South Carolina | 35 | |||
| 10/13/2012 | South Carolina | 21 | at | LSU (10-3,6-2) | 23 | |||
| 10/20/2012 | South Carolina | 11 | at | Florida (11-2,7-1) | 44 | |||
| 10/27/2012 | Tennessee (5-7,1-7) | 35 | at | South Carolina | 38 | |||
| 11/10/2012 | Arkansas (4-8,2-6) | 20 | at | South Carolina | 38 | |||
| 11/17/2012 | Wofford (9-4) | 7 | at | South Carolina | 24 | SoCon (1AA) | ||
| 11/24/2012 | South Carolina | 27 | at | Clemson (11-2) | 17 | at ACC | ||
| 1/1/2013 | South Carolina | 33 | vs | Michigan (8-5) | 28 | Outback Bowl | vs B10 |
| vs South Carolina | vs Other Opponents | South Carolina compared to OOs | |
| Record: | 2-11 | 95-57 | |
| Points Scored: | 18.23 | 30.90 | 12.67 |
| Points Allowed: | 31.54 | 24.26 | 7.28 |
| Margin: | -13.31 | 6.64 | 19.95 |
| Total Points: | 49.77 | 55.16 | -5.39 |