| 9/1/2012 | Clemson | 26 | vs | Auburn (3-9) | 19 | Atlanta GA | vs SEC | |
| 9/8/2012 | Ball State (9-4) | 27 | at | Clemson | 52 | MAC | ||
| 9/15/2012 | Furman (3-8) | 7 | at | Clemson | 41 | SoCon (1AA) | ||
| 9/22/2012 | Clemson | 37 | at | Florida State (12-2,8-1) | 49 | |||
| 9/29/2012 | Clemson | 45 | at | Boston College (2-10,1-7) | 31 | |||
| 10/6/2012 | Georgia Tech (7-7,5-4) | 31 | at | Clemson | 47 | |||
| 10/20/2012 | Virginia Tech (7-6,4-4) | 17 | at | Clemson | 38 | |||
| 10/25/2012 | Clemson | 42 | at | Wake Forest (5-7,3-5) | 13 | |||
| 11/3/2012 | Clemson | 56 | at | Duke (6-7,3-5) | 20 | |||
| 11/10/2012 | Maryland (4-8,2-6) | 10 | at | Clemson | 45 | |||
| 11/17/2012 | North Carolina State (7-6,4-4) | 48 | at | Clemson | 62 | |||
| 11/24/2012 | South Carolina (11-2) | 27 | at | Clemson | 17 | SEC | ||
| 12/31/2012 | LSU (10-3) | 24 | vs | Clemson | 25 | Chick-fil-A Bowl | SEC |
| vs Clemson | vs Other Opponents | Clemson compared to OOs | |
| Record: | 2-11 | 84-68 | |
| Points Scored: | 24.85 | 27.84 | 2.99 |
| Points Allowed: | 41.00 | 24.92 | 16.08 |
| Margin: | -16.15 | 2.92 | 19.07 |
| Total Points: | 65.85 | 52.76 | 13.09 |