| 9/1/2012 | Southeastern Louisiana (5-6) | 10 | at | Missouri | 62 | SLC (1AA) | ||
| 9/8/2012 | Georgia (12-2,7-2) | 41 | at | Missouri | 20 | |||
| 9/15/2012 | Arizona State (8-5) | 20 | at | Missouri | 24 | P12 | ||
| 9/22/2012 | Missouri | 10 | at | South Carolina (11-2,6-2) | 31 | |||
| 9/29/2012 | Missouri | 21 | at | UCF (10-4) | 16 | at CUSA | ||
| 10/6/2012 | Vanderbilt (9-4,5-3) | 19 | at | Missouri | 15 | |||
| 10/13/2012 | Alabama (13-1,8-1) | 42 | at | Missouri | 10 | |||
| 10/27/2012 | Kentucky (2-10,0-8) | 10 | at | Missouri | 33 | |||
| 11/3/2012 | Missouri | 7 | at | Florida (11-2,7-1) | 14 | |||
| 11/10/2012 | Missouri | 51 | at | Tennessee (5-7,1-7) | 48 | 4OT | ||
| 11/17/2012 | Syracuse (8-5) | 31 | at | Missouri | 27 | BigE | ||
| 11/24/2012 | Missouri | 29 | at | Texas A&M (11-2,6-2) | 59 |
| vs Missouri | vs Other Opponents | Missouri compared to OOs | |
| Record: | 7-5 | 98-45 | |
| Points Scored: | 28.42 | 32.82 | 4.40 |
| Points Allowed: | 25.75 | 22.37 | 3.38 |
| Margin: | 2.67 | 10.45 | 7.78 |
| Total Points: | 54.17 | 55.19 | -1.02 |