| 9/1/2012 | South Dakota State (9-4) | 17 | at | Kansas | 31 | MVC (1AA) | ||
| 9/8/2012 | Rice (7-6) | 25 | at | Kansas | 24 | CUSA | ||
| 9/15/2012 | TCU (7-6,4-5) | 20 | at | Kansas | 6 | |||
| 9/22/2012 | Kansas | 23 | at | Northern Illinois (12-2) | 30 | at MAC | ||
| 10/6/2012 | Kansas | 16 | at | Kansas State (11-2,8-1) | 56 | |||
| 10/13/2012 | Oklahoma State (8-5,5-4) | 20 | at | Kansas | 14 | |||
| 10/20/2012 | Kansas | 7 | at | Oklahoma (10-3,8-1) | 52 | |||
| 10/27/2012 | Texas (9-4,5-4) | 21 | at | Kansas | 17 | |||
| 11/3/2012 | Kansas | 14 | at | Baylor (8-5,4-5) | 41 | |||
| 11/10/2012 | Kansas | 34 | at | Texas Tech (8-5,4-5) | 41 | 2OT | ||
| 11/17/2012 | Iowa State (6-7,3-6) | 51 | at | Kansas | 23 | |||
| 12/1/2012 | Kansas | 10 | at | West Virginia (7-6,4-5) | 59 |
| vs Kansas | vs Other Opponents | Kansas compared to OOs | |
| Record: | 11-1 | 91-54 | |
| Points Scored: | 36.08 | 35.51 | -0.57 |
| Points Allowed: | 18.25 | 27.75 | -9.50 |
| Margin: | 17.83 | 7.76 | -10.07 |
| Total Points: | 54.33 | 63.26 | -8.93 |