| 9/1/2012 | Texas State (4-8) | 30 | at | Houston | 13 | WAC | ||
| 9/8/2012 | Louisiana Tech (9-3) | 56 | at | Houston | 49 | WAC | ||
| 9/15/2012 | Houston | 6 | at | UCLA (9-5) | 37 | at P12 | ||
| 9/29/2012 | Houston | 35 | vs | Rice (7-6,4-4) | 14 | Houston TX | ||
| 10/6/2012 | North Texas (4-8) | 21 | at | Houston | 44 | SBC | ||
| 10/13/2012 | UAB (3-9,2-6) | 17 | at | Houston | 39 | |||
| 10/18/2012 | Houston | 42 | at | SMU (7-6,5-3) | 72 | |||
| 10/27/2012 | UTEP (3-9,2-6) | 35 | at | Houston | 45 | |||
| 11/3/2012 | Houston | 28 | at | East Carolina (8-5,7-1) | 48 | |||
| 11/10/2012 | Tulsa (11-3,8-1) | 41 | at | Houston | 7 | |||
| 11/17/2012 | Houston | 41 | at | Marshall (5-7,4-4) | 44 | |||
| 11/24/2012 | Tulane (2-10,2-6) | 17 | at | Houston | 40 |
| vs Houston | vs Other Opponents | Houston compared to OOs | |
| Record: | 7-5 | 65-74 | |
| Points Scored: | 36.00 | 31.00 | -5.00 |
| Points Allowed: | 32.42 | 31.99 | 0.43 |
| Margin: | 3.58 | -0.99 | -4.57 |
| Total Points: | 68.42 | 62.99 | 5.43 |