| 9/1/2012 | Florida Intl (3-9) | 26 | at | Duke | 46 | SBC | ||
| 9/8/2012 | Duke | 13 | at | Stanford (12-2) | 50 | at P12 | ||
| 9/15/2012 | North Carolina Central (6-5) | 17 | at | Duke | 54 | MEAC (1AA) | ||
| 9/22/2012 | Memphis (4-8) | 14 | at | Duke | 38 | CUSA | ||
| 9/29/2012 | Duke | 34 | at | Wake Forest (5-7,3-5) | 27 | |||
| 10/6/2012 | Virginia (4-8,2-6) | 17 | at | Duke | 42 | |||
| 10/13/2012 | Duke | 20 | at | Virginia Tech (7-6,4-4) | 41 | |||
| 10/20/2012 | North Carolina (8-4,5-3) | 30 | at | Duke | 33 | |||
| 10/27/2012 | Duke | 7 | at | Florida State (12-2,8-1) | 48 | |||
| 11/3/2012 | Clemson (11-2,7-1) | 56 | at | Duke | 20 | |||
| 11/17/2012 | Duke | 24 | at | Georgia Tech (7-7,5-4) | 42 | |||
| 11/24/2012 | Miami-Florida (7-5,5-3) | 52 | at | Duke | 45 | |||
| 12/27/2012 | Cincinnati (10-3) | 48 | vs | Duke | 34 | Belk Bowl | BigE |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 7-6 | 89-62 | |
| Points Scored: | 36.00 | 29.68 | -6.32 |
| Points Allowed: | 31.54 | 24.83 | 6.71 |
| Margin: | 4.46 | 4.85 | 0.39 |
| Total Points: | 67.54 | 54.51 | 13.03 |