| 9/3/2012 | Georgia Tech (7-7,5-4) | 17 | at | Virginia Tech | 20 | OT | ||
| 9/8/2012 | Austin Peay (2-9) | 7 | at | Virginia Tech | 42 | OVC (1AA) | ||
| 9/15/2012 | Virginia Tech | 17 | at | Pittsburgh (6-7) | 35 | at BigE | ||
| 9/22/2012 | Bowling Green (8-5) | 0 | at | Virginia Tech | 37 | MAC | ||
| 9/29/2012 | Cincinnati (10-3) | 27 | vs | Virginia Tech | 24 | Landover MD | BigE | |
| 10/6/2012 | Virginia Tech | 34 | at | North Carolina (8-4,5-3) | 48 | |||
| 10/13/2012 | Duke (6-7,3-5) | 20 | at | Virginia Tech | 41 | |||
| 10/20/2012 | Virginia Tech | 17 | at | Clemson (11-2,7-1) | 38 | |||
| 11/1/2012 | Virginia Tech | 14 | at | Miami-Florida (7-5,5-3) | 30 | |||
| 11/8/2012 | Florida State (12-2,8-1) | 28 | at | Virginia Tech | 22 | |||
| 11/17/2012 | Virginia Tech | 30 | at | Boston College (2-10,1-7) | 23 | OT | ||
| 11/24/2012 | Virginia (4-8,2-6) | 14 | at | Virginia Tech | 17 | |||
| 12/28/2012 | Rutgers (9-4) | 10 | vs | Virginia Tech | 13 | Russell Athletic Bowl | BigE |
| vs Virginia Tech | vs Other Opponents | Virginia Tech compared to OOs | |
| Record: | 6-7 | 86-66 | |
| Points Scored: | 22.85 | 30.30 | 7.45 |
| Points Allowed: | 25.23 | 24.97 | 0.26 |
| Margin: | -2.38 | 5.33 | 7.71 |
| Total Points: | 48.08 | 55.27 | -7.19 |