| 9/4/2010 | Missouri S&T 7 @ Emporia State Hornets 23 | |
| 9/11/2010 | Drake Bulldogs 28 @ Missouri S&T 14 | |
| 9/18/2010 | Missouri S&T 10 @ Wisconsin-Stevens Point Pointers 29 | |
| 9/25/2010 | Wisconsin-La Crosse Eagles 24 @ Missouri S&T 31 | |
| 10/2/2010 | Northwestern Oklahoma State Rangers 43 @ Missouri S&T 14 | |
| 10/9/2010 | Missouri S&T 6 @ South Alabama Jaguars 45 | |
| 10/16/2010 | Kentucky Wesleyan Panthers 35 @ Missouri S&T 38 | † |
| 10/23/2010 | Missouri S&T 14 @ St Francis IN Fighting Saints 41 | |
| 10/30/2010 | Urbana Blue Knights 42 @ Missouri S&T 25 | † |
| 11/6/2010 | Missouri S&T 27 @ St Joseph's Pumas 21 | † |
| 11/13/2010 | Missouri S&T 20 @ Lincoln MO Blue Tigers 21 |