| 9/4/2010 | Northwood 19 @ Wayne State MI Warriors 31 | † |
| 9/11/2010 | Northwood 28 @ Ohio Dominican Panthers 12 | † |
| 9/18/2010 | Northern Michigan Wildcats 31 @ Northwood 17 | † |
| 9/25/2010 | Saginaw Valley State Cardinals 26 @ Northwood 30 | † |
| 10/2/2010 | Northwood 17 @ Ashland Eagles 37 | † |
| 10/9/2010 | Northwood 31 @ Indianapolis Greyhounds 24 | † |
| 10/16/2010 | Tiffin Dragons 27 @ Northwood 51 | † |
| 10/23/2010 | Northwood 30 @ Michigan Tech Huskies 62 | † |
| 10/30/2010 | Hillsdale Chargers 35 @ Northwood 28 | † |
| 11/6/2010 | Northwood 21 @ Grand Valley State Lakers 35 | † |
| 11/13/2010 | Ferris State Bulldogs 35 @ Northwood 41 | † |