| 9/3/2010 | Ferris State 17 @ Hillsdale Chargers 35 | † |
| 9/11/2010 | Saginaw Valley State Cardinals 17 @ Ferris State 21 | † |
| 9/18/2010 | Ferris State 34 @ Ohio Dominican Panthers 28 | † |
| 9/25/2010 | Tiffin Dragons 28 @ Ferris State 52 | † |
| 10/2/2010 | Ferris State 22 @ Lake Erie Storm 12 | † |
| 10/9/2010 | Findlay Oilers 10 @ Ferris State 23 | † |
| 10/16/2010 | Ferris State 20 @ Northern Michigan Wildcats 22 | † |
| 10/23/2010 | Grand Valley State Lakers 41 @ Ferris State 0 | † |
| 10/30/2010 | Ferris State 33 @ Indianapolis Greyhounds 37 | † |
| 11/6/2010 | Michigan Tech Huskies 28 @ Ferris State 16 | † |
| 11/13/2010 | Ferris State 35 @ Northwood Timberwolves 41 | † |