| 9/4/2010 | Northwood Timberwolves 19 @ Wayne State MI 31 | † |
| 9/11/2010 | Wayne State MI 63 @ Tiffin Dragons 14 | † |
| 9/18/2010 | Wayne State MI 7 @ Michigan Tech Huskies 24 | † |
| 9/25/2010 | Ohio Dominican Panthers 7 @ Wayne State MI 17 | † |
| 10/2/2010 | Northern Michigan Wildcats 18 @ Wayne State MI 26 | † |
| 10/9/2010 | Wayne State MI 28 @ Lake Erie Storm 16 | † |
| 10/16/2010 | Ashland Eagles 40 @ Wayne State MI 35 | † |
| 10/23/2010 | Hillsdale Chargers 9 @ Wayne State MI 14 | † |
| 10/30/2010 | Wayne State MI 41 @ Saginaw Valley State Cardinals 27 | † |
| 11/6/2010 | Indianapolis Greyhounds 27 @ Wayne State MI 41 | † |
| 11/13/2010 | Wayne State MI 44 @ Findlay Oilers 27 | † |