| 9/3/2010 | Ferris State Bulldogs 17 @ Hillsdale 35 | † |
| 9/11/2010 | Hillsdale 41 @ Grand Valley State Lakers 44 | † |
| 9/18/2010 | Hillsdale 27 @ Ashland Eagles 17 | † |
| 9/25/2010 | Lake Erie Storm 37 @ Hillsdale 42 | † |
| 10/2/2010 | Saginaw Valley State Cardinals 21 @ Hillsdale 35 | † |
| 10/9/2010 | Hillsdale 35 @ Ohio Dominican Panthers 10 | † |
| 10/16/2010 | Michigan Tech Huskies 17 @ Hillsdale 24 | † |
| 10/23/2010 | Hillsdale 9 @ Wayne State MI Warriors 14 | † |
| 10/30/2010 | Hillsdale 35 @ Northwood Timberwolves 28 | † |
| 11/6/2010 | Findlay Oilers 3 @ Hillsdale 31 | † |
| 11/13/2010 | Tiffin Dragons 24 @ Hillsdale 31 | † |
| 11/20/2010 | Hillsdale 28 @ Saint Cloud State Huskies 42 |