| 9/4/2010 | Louisiana Tech | vs | Grambling | ||||||
| 9/18/2010 | Jackson St | @ | Grambling | SWAC | |||||
| 9/25/2010 | Grambling | vs | Prairie View | SWAC | |||||
| 10/2/2010 | Grambling | @ | Alabama A&M | SWAC | |||||
| 10/9/2010 | Alabama St | @ | Grambling | SWAC | |||||
| 10/16/2010 | Alcorn St | @ | Grambling | SWAC | |||||
| 10/23/2010 | Grambling | @ | MS Valley St | SWAC | |||||
| 10/30/2010 | Grambling | vs | Ark Pine Bluff | SWAC | |||||
| 11/6/2010 | Concordia AL NAIA | @ | Grambling | ||||||
| 11/13/2010 | Grambling | @ | Texas Southern | SWAC | |||||
| 11/27/2010 | Grambling | vs | Southern Univ | SWAC |