| 9/4/2010 | Langston NAIA | @ | Alcorn St | ||||||
| 9/18/2010 | Alcorn St | @ | MS Valley St | SWAC | |||||
| 9/25/2010 | Alabama St | @ | Alcorn St | SWAC | |||||
| 10/2/2010 | Alcorn St | @ | Mississippi St | ||||||
| 10/9/2010 | Texas Southern | @ | Alcorn St | SWAC | |||||
| 10/16/2010 | Alcorn St | @ | Grambling | SWAC | |||||
| 10/21/2010 | Ark Pine Bluff | @ | Alcorn St | SWAC | |||||
| 10/30/2010 | Southern Univ | @ | Alcorn St | SWAC | |||||
| 11/6/2010 | Alcorn St | @ | Alabama A&M | SWAC | |||||
| 11/13/2010 | Alcorn St | @ | Prairie View | SWAC | |||||
| 11/20/2010 | Alcorn St | @ | Jackson St | SWAC |