| 9/5/2010 | Prairie View | @ | Texas Southern | SWAC | |||||
| 9/11/2010 | Texas Southern | @ | Connecticut | ||||||
| 9/18/2010 | Alabama A&M | @ | Texas Southern | SWAC | |||||
| 10/2/2010 | Texas Southern | @ | Alabama St | SWAC | |||||
| 10/9/2010 | Texas Southern | @ | Alcorn St | SWAC | |||||
| 10/23/2010 | Jackson St | @ | Texas Southern | SWAC | |||||
| 10/30/2010 | MS Valley St | @ | Texas Southern | SWAC | |||||
| 11/6/2010 | Texas Southern | @ | Southern Univ | SWAC | |||||
| 11/13/2010 | Grambling | @ | Texas Southern | SWAC | |||||
| 11/20/2010 | Ark Pine Bluff | @ | Texas Southern | SWAC |