| 9/5/2010 | Prairie View | @ | Texas Southern | SWAC | |||||
| 9/11/2010 | Prairie View | @ | Southern Miss | ||||||
| 9/18/2010 | Alabama St | @ | Prairie View | SWAC | |||||
| 9/25/2010 | Grambling | vs | Prairie View | SWAC | |||||
| 10/2/2010 | Prairie View | @ | MS Valley St | SWAC | |||||
| 10/9/2010 | Prairie View | @ | Ark Pine Bluff | SWAC | |||||
| 10/16/2010 | Lincoln MO D2 | @ | Prairie View | ||||||
| 10/23/2010 | Prairie View | vs | Southern Univ | SWAC | |||||
| 10/30/2010 | Prairie View | @ | Jackson St | SWAC | |||||
| 11/13/2010 | Alcorn St | @ | Prairie View | SWAC | |||||
| 11/20/2010 | Prairie View | @ | Alabama A&M | SWAC |