| 9/4/2010 | Elon 1AA | 27 | @ | Duke | 41 | ||||
| 9/11/2010 | Duke | 48 | @ | Wake Forest | 54 | ACC | |||
| 9/18/2010 | Alabama | 62 | @ | Duke | 13 | ||||
| 9/25/2010 | Army | 35 | @ | Duke | 21 | ||||
| 10/2/2010 | Duke | 16 | @ | Maryland | 21 | ACC | |||
| 10/16/2010 | Miami-Florida | 28 | @ | Duke | 13 | ACC | |||
| 10/23/2010 | Duke | 7 | @ | Virginia Tech | 44 | ACC | |||
| 10/30/2010 | Duke | 34 | @ | Navy | 31 | ||||
| 11/6/2010 | Virginia | 48 | @ | Duke | 56 | ACC | |||
| 11/13/2010 | Boston College | 21 | @ | Duke | 16 | ACC | |||
| 11/20/2010 | Duke | 20 | @ | Georgia Tech | 30 | ACC | |||
| 11/27/2010 | North Carolina | 24 | @ | Duke | 19 | ACC |