| Thursday, 23 Nov 2006 | |||||||
| Tuskegee (D2) | 17 | @ | Alabama St | 10 | |||
| ACC | #18 Boston College | 14 | @ | Miami FL | 17 | ||
| Friday, 24 Nov 2006 | |||||||
| MAC | Western Michigan | 17 | @ | Akron | 0 | ||
| SEC | #8 LSU | 31 | vs | #5 Arkansas | 26 | Little Rock AR | |
| MAC | Kent St | 6 | @ | Ball St | 30 | ||
| MAC | Central Michigan | 55 | @ | Buffalo | 28 | ||
| MAC | Northern Illinois | 27 | @ | Eastern Michigan | 0 | ||
| WAC | Fresno St | 34 | @ | Louisiana Tech | 27 | ||
| MAC | Ohio U. | 34 | @ | Miami OH | 24 | ||
| B12 | Colorado | 14 | @ | #19 Nebraska | 37 | ||
| P10 | Oregon | 28 | @ | Oregon St | 30 | ||
| B12 | Texas A&M | 12 | @ | #10 Texas | 7 | ||
| CUSA | Tulane | 3 | @ | Tulsa | 38 | ||
| MW | Air Force | 39 | @ | UNLV | 42 | ||
| Saturday, 25 Nov 2006 | |||||||
| Coastal Carolina | 28 | @ | Appalachian St | 45 | 1-AA Playoffs | ||
| P10 | Arizona St | 28 | @ | Arizona | 14 | ||
| PSAC | West Chester (D2) | 20 | @ | Bloomsburg (D2) | 21 | D-II Playoffs | |
| North Central (D3) | 13 | @ | Capital (D3) | 41 | D-III Playoffs | ||
| St Xavier (NAIA) | 14 | @ | Carroll MT (NAIA) | 7 | |||
| CUSA | Alabama-Birmingham | 22 | @ | Central Florida | 31 | ||
| West Texas A&M (D2) | 17 | @ | Chadron St (D2) | 43 | D-II Playoffs | ||
| South Carolina | 31 | @ | #24 Clemson | 28 | |||
| MW | TCU | 45 | @ | Colorado St | 14 | ||
| BigE | Cincinnati | 26 | @ | Connecticut | 23 | ||
| ACC | North Carolina | 45 | @ | Duke | 44 | ||
| Illinois St | 24 | @ | Eastern Illinois | 13 | 1-AA Playoffs | ||
| SBC | Florida Int'l | 0 | vs | Florida Atlantic | 31 | Miami FL | |
| #4 Florida | 21 | @ | Florida St | 14 | |||
| #15 Georgia Tech | 12 | @ | Georgia | 15 | |||
| South Dakota (D2) | 17 | @ | Grand Valley St (D2) | 35 | D-II Playoffs | ||
| New Hampshire | 41 | @ | Hampton | 38 | 1-AA Playoffs | ||
| Purdue | 35 | @ | #25 Hawaii | 42 | |||
| WAC | San Jose St | 28 | @ | Idaho | 13 | ||
| SBC | Arkansas St | 13 | @ | Louisiana-Lafayette | 28 | ||
| SBC | North Texas | 3 | @ | Louisiana-Monroe | 23 | ||
| Wash & Jeff (D3) | 27 | @ | Mary Hardin-Baylor (D3) | 30 | D-III Playoffs | ||
| ACC | #20 Wake Forest | 38 | @ | Maryland | 24 | ||
| Lafayette | 14 | @ | Massachusetts | 35 | 1-AA Playoffs | ||
| SBC | Troy | 21 | @ | Middle Tennessee St | 20 | ||
| SEC | Mississippi St | 17 | @ | Mississippi | 20 | ||
| B12 | Kansas | 17 | @ | Missouri | 42 | ||
| Northwestern IA (NAIA) | 26 | @ | Missouri Valley (NAIA) | 33 | |||
| McNeese St | 6 | @ | Montana | 31 | 1-AA Playoffs | ||
| Furman | 13 | @ | Montana St | 31 | 1-AA Playoffs | ||
| Wheaton (D3) | 3 | @ | Mount Union (D3) | 35 | D-III Playoffs | ||
| NCC | North Dakota (D2) | 38 | @ | Nebraska-Omaha (D2) | 35 | D-II Playoffs | |
| WAC | #12 Boise St | 38 | @ | Nevada | 7 | ||
| MW | San Diego St | 14 | @ | New Mexico | 41 | ||
| Newberry (D2) | 20 | @ | North Alabama (D2) | 38 | D-II Playoffs | ||
| Delta St (D2) | 24 | @ | North Carolina Central (D2) | 17 | D-II Playoffs | ||
| East Carolina | 21 | @ | North Carolina St | 16 | |||
| Midwestern St (D2) | 0 | @ | NW Missouri St (D2) | 27 | D-II Playoffs | ||
| B12 | #13 Oklahoma | 27 | @ | Oklahoma St | 21 | ||
| BigE | #8 Louisville | 48 | @ | Pittsburgh | 24 | ||
| CUSA | SMU | 27 | @ | Rice | 31 | ||
| BigE | Syracuse | 7 | @ | #15 Rutgers | 38 | ||
| Merrimack (D2) | 7 | @ | Shepherd (D2) | 31 | D-II Playoffs | ||
| GPAC | Morningside (NAIA) | 7 | @ | Sioux Falls (NAIA) | 37 | ||
| #5 Notre Dame | 24 | @ | #2 Southern Cal | 44 | |||
| Tennessee-Martin | 30 | @ | Southern Illinois | 36 | 1-AA Playoffs | ||
| CUSA | Marshall | 7 | @ | Southern Miss | 42 | ||
| SWAC | Grambling St | 17 | vs | Southern U. | 21 | New Orleans LA | |
| E8 | St John Fisher (D3) | 27 | @ | Springfield (D3) | 21 | D-III Playoffs | |
| Bethel TN (NAIA) | 35 | @ | St Francis IN (NAIA) | 42 | |||
| SEC | Kentucky | 12 | @ | #19 Tennessee | 17 | ||
| San Diego | 27 | @ | UC-Davis | 37 | |||
| MW | #21 Brigham Young | 33 | @ | Utah | 31 | ||
| WAC | New Mexico St | 42 | @ | Utah St | 20 | ||
| CUSA | Memphis | 38 | @ | UTEP | 19 | ||
| WIAC | UW-La Crosse (D3) | 21 | @ | UW-Whitewater (D3) | 24 | D-III Playoffs | |
| ACC | Virginia | 0 | @ | #17 Virginia Tech | 17 | ||
| Carnegie Mellon (D3) | 0 | @ | Wesley (D3) | 37 | D-III Playoffs | ||
| BigE | South Florida | 24 | @ | #7 West Virginia | 19 | ||
| St John's MN (D3) | 21 | @ | Whitworth (D3) | 3 | D-III Playoffs | ||
| Rowan (D3) | 21 | @ | Wilkes (D3) | 14 | D-III Playoffs | ||
| James Madison | 31 | @ | Youngstown St | 35 | 1-AA Playoffs | ||