| 9/2/2006 | Northeastern | 0 | @ | #14 Virginia Tech | 38 | ||||
| 9/9/2006 | #14 Virginia Tech | 35 | @ | North Carolina | 10 | ACC | |||
| 9/16/2006 | Duke | 0 | @ | #14 Virginia Tech | 36 | ACC | |||
| 9/23/2006 | Cincinnati | 13 | @ | #14 Virginia Tech | 29 | ||||
| 9/30/2006 | #25 Georgia Tech | 38 | @ | #14 Virginia Tech | 27 | ACC | |||
| 10/12/2006 | #14 Virginia Tech | 3 | @ | #23 Boston College | 22 | ACC | |||
| 10/21/2006 | Southern Miss | 6 | @ | #14 Virginia Tech | 36 | ||||
| 10/26/2006 | Clemson | 7 | @ | #14 Virginia Tech | 24 | ACC | |||
| 11/4/2006 | #14 Virginia Tech | 17 | @ | Miami-Florida | 10 | ACC | |||
| 11/11/2006 | Kent St | 0 | @ | #14 Virginia Tech | 23 | ||||
| 11/18/2006 | #14 Virginia Tech | 27 | @ | #14 Wake Forest | 6 | ACC | |||
| 11/25/2006 | Virginia | 0 | @ | #14 Virginia Tech | 17 | ACC | |||
| 12/30/2006 | #14 Virginia Tech | 24 | vs | Georgia | 31 | Chik-Fil-A |