| 9/2/2006 | East Carolina | 23 | @ | Navy | 28 | ||||
| 9/9/2006 | East Carolina | 12 | @ | UAB | 17 | CUSA | |||
| 9/16/2006 | Memphis | 20 | @ | East Carolina | 35 | CUSA | |||
| 9/23/2006 | #12 West Virginia | 27 | @ | East Carolina | 10 | ||||
| 10/7/2006 | Virginia | 21 | @ | East Carolina | 31 | ||||
| 10/14/2006 | Tulsa | 31 | @ | East Carolina | 10 | CUSA | |||
| 10/21/2006 | SMU | 21 | @ | East Carolina | 38 | CUSA | |||
| 10/28/2006 | East Carolina | 20 | @ | Southern Miss | 17 | OT | CUSA | ||
| 11/4/2006 | East Carolina | 23 | @ | UCF | 10 | CUSA | |||
| 11/11/2006 | Marshall | 20 | @ | East Carolina | 33 | CUSA | |||
| 11/18/2006 | East Carolina | 17 | @ | Rice | 18 | CUSA | |||
| 11/25/2006 | East Carolina | 21 | @ | North Carolina St | 16 | ||||
| 12/23/2006 | South Florida | 24 | vs | East Carolina | 7 | PapaJohns |