| 8/28/2021 | Northwestern IA | 66 | at | Presentation (0-11) | 9 | at NSAA | ||
| 9/4/2021 | Hastings (2-8,2-8) | 13 | at | Northwestern IA | 45 | |||
| 9/11/2021 | Northwestern IA | 35 | at | Midland U. (6-5,6-4) | 29 | OT | ||
| 9/18/2021 | Doane (5-5,5-5) | 0 | at | Northwestern IA | 38 | |||
| 9/25/2021 | Northwestern IA | 31 | at | Concordia NE (7-3,7-3) | 7 | |||
| 10/2/2021 | Northwestern IA | 56 | at | Mount Marty (0-10,0-10) | 17 | |||
| 10/16/2021 | Northwestern IA | 63 | at | Jamestown (2-9,2-8) | 7 | |||
| 10/23/2021 | Northwestern IA | 50 | at | Dakota Wesleyan (4-7,4-6) | 0 | |||
| 10/30/2021 | Dordt (7-3,7-3) | 28 | at | Northwestern IA | 63 | |||
| 11/6/2021 | Morningside (14-0,11-0) | 55 | at | Northwestern IA | 49 | |||
| 11/13/2021 | Northwestern IA | 63 | at | Briar Cliff (3-8,3-7) | 7 | |||
| 11/20/2021 | Central Methodist (9-3) | 7 | at | Northwestern IA | 24 | HAAC | ||
| 11/27/2021 | Marian IN (9-3) | 20 | at | Northwestern IA | 25 | MSFA | ||
| 12/4/2021 | Northwestern IA | 19 | at | Morningside (14-0,11-0) | 28 |
| vs Northwestern IA | vs Other Opponents | Northwestern IA compared to OOs | |
| Record: | 2-12 | 78-63 | |
| Points Scored: | 16.21 | 30.13 | 13.92 |
| Points Allowed: | 44.79 | 25.60 | 19.19 |
| Margin: | -28.58 | 4.53 | 33.11 |
| Total Points: | 61.00 | 55.73 | 5.27 |