| 8/28/2021 | Dakota State (6-4) | 6 | at | Dakota Wesleyan | 0 | NSAA | ||
| 9/4/2021 | Dakota Wesleyan | 20 | at | Mount Marty (0-10,0-10) | 3 | |||
| 9/18/2021 | Dakota Wesleyan | 14 | at | Midland U. (6-5,6-4) | 27 | |||
| 9/25/2021 | Hastings (2-8,2-8) | 16 | at | Dakota Wesleyan | 27 | |||
| 10/2/2021 | Dakota Wesleyan | 0 | at | Concordia NE (7-3,7-3) | 34 | |||
| 10/9/2021 | Doane (5-5,5-5) | 13 | at | Dakota Wesleyan | 17 | |||
| 10/16/2021 | Dakota Wesleyan | 13 | at | Dordt (7-3,7-3) | 45 | |||
| 10/23/2021 | Northwestern IA (12-2,9-2) | 50 | at | Dakota Wesleyan | 0 | |||
| 10/30/2021 | Dakota Wesleyan | 14 | at | Briar Cliff (3-8,3-7) | 20 | |||
| 11/6/2021 | Jamestown (2-9,2-8) | 25 | at | Dakota Wesleyan | 31 | |||
| 11/13/2021 | Morningside (14-0,11-0) | 52 | at | Dakota Wesleyan | 7 |
| vs Dakota Wesleyan | vs Other Opponents | Dakota Wesleyan compared to OOs | |
| Record: | 7-4 | 57-53 | |
| Points Scored: | 26.45 | 28.98 | 2.53 |
| Points Allowed: | 13.00 | 27.91 | -14.91 |
| Margin: | 13.45 | 1.07 | -12.38 |
| Total Points: | 39.45 | 56.89 | -17.44 |