| 8/28/2021 | Central Methodist | 10 | at | Grand View (14-1,11-0) | 37 | | | |
| 9/4/2021 | Peru State (7-4,7-4) | 24 | at | Central Methodist | 27 | | | |
| 9/11/2021 | Central Methodist | 31 | at | Clarke (1-10,1-10) | 16 | | | |
| 9/18/2021 | Graceland (0-11,0-11) | 0 | at | Central Methodist | 44 | | | |
| 9/25/2021 | Central Methodist | 36 | at | Culver-Stockton (8-3,8-3) | 44 | | | |
| 10/2/2021 | William Penn (3-8,3-8) | 27 | at | Central Methodist | 28 | | | |
| 10/16/2021 | Benedictine KS (7-4,7-4) | 24 | at | Central Methodist | 30 | | | |
| 10/23/2021 | Central Methodist | 41 | at | MidAmerica Nazarene (3-8,3-8) | 24 | | | |
| 10/30/2021 | Missouri Valley (3-8,3-8) | 7 | at | Central Methodist | 41 | | | |
| 11/6/2021 | Baker (9-2,9-2) | 19 | at | Central Methodist | 21 | | | |
| 11/13/2021 | Central Methodist | 17 | at | Evangel (5-6,5-6) | 7 | | | |
| 11/20/2021 | Central Methodist | 7 | at | Northwestern IA (12-2) | 24 | | | at GPAC |