| 9/4/2021 | Tiffin (8-3) | 34 | at | Marian IN | 10 | GMAC (D2) | ||
| 9/11/2021 | Marian IN | 80 | at | Madonna (0-8,0-8) | 3 | |||
| 9/18/2021 | Marian IN | 40 | at | St Francis IL (6-3,6-3) | 17 | |||
| 9/25/2021 | Missouri Baptist (4-7,2-7) | 0 | at | Marian IN | 49 | |||
| 10/2/2021 | Marian IN | 51 | at | Taylor (2-8,2-7) | 7 | |||
| 10/9/2021 | Marian IN | 7 | at | Indiana Wesleyan (7-1,6-1) | 41 | |||
| 10/16/2021 | St Francis IN (3-6,3-6) | 10 | at | Marian IN | 56 | |||
| 10/23/2021 | Concordia MI (9-2,9-1) | 7 | at | Marian IN | 25 | |||
| 11/6/2021 | Marian IN | 28 | at | Siena Heights (4-5,4-5) | 6 | |||
| 11/13/2021 | Lawrence Tech (5-3,4-3) | 7 | at | Marian IN | 41 | |||
| 11/20/2021 | Southwestern (9-2) | 17 | at | Marian IN | 21 | KCAC | ||
| 11/27/2021 | Marian IN | 20 | at | Northwestern IA (12-2) | 25 | at GPAC |
| vs Marian IN | vs Other Opponents | Marian IN compared to OOs | |
| Record: | 3-9 | 66-41 | |
| Points Scored: | 14.50 | 29.99 | 15.49 |
| Points Allowed: | 35.67 | 22.96 | 12.71 |
| Margin: | -21.17 | 7.03 | 28.20 |
| Total Points: | 50.17 | 52.95 | -2.78 |