| 9/4/2021 | Ave Maria (5-6,5-5) | 10 | at | Georgetown KY | 42 | |||
| 9/11/2021 | Georgetown KY | 31 | at | Webber International (2-8,2-8) | 21 | |||
| 9/25/2021 | Georgetown KY | 61 | at | Bluefield (6-5,5-5) | 19 | |||
| 10/2/2021 | Pikeville (4-5,4-5) | 14 | at | Georgetown KY | 52 | |||
| 10/9/2021 | Georgetown KY | 24 | at | Bethel TN (7-4,7-3) | 25 | |||
| 10/16/2021 | Georgetown KY | 0 | at | Lindsey Wilson (12-1,11-0) | 35 | |||
| 10/23/2021 | Thomas More (5-5,5-5) | 17 | at | Georgetown KY | 27 | |||
| 10/30/2021 | Georgetown KY | 42 | at | Campbellsville (1-9,1-9) | 3 | |||
| 11/6/2021 | Cumberlands KY (6-4,6-4) | 7 | at | Georgetown KY | 28 | |||
| 11/13/2021 | Cumberland TN (3-7,3-7) | 10 | at | Georgetown KY | 28 |
| vs Georgetown KY | vs Other Opponents | Georgetown KY compared to OOs | |
| Record: | 2-8 | 49-46 | |
| Points Scored: | 16.10 | 30.00 | 13.90 |
| Points Allowed: | 33.50 | 28.05 | 5.45 |
| Margin: | -17.40 | 1.95 | 19.35 |
| Total Points: | 49.60 | 58.05 | -8.45 |