| 9/4/2021 | Thomas More | 45 | at | Bluefield (6-5,5-5) | 33 | |||
| 9/11/2021 | Faulkner (7-2,7-2) | 27 | at | Thomas More | 20 | |||
| 9/18/2021 | Thomas More | 14 | at | Southeastern FL (7-3,7-3) | 20 | |||
| 9/30/2021 | Thomas More | 73 | at | Campbellsville (1-9,1-9) | 28 | |||
| 10/9/2021 | Lindsey Wilson (12-1,11-0) | 47 | at | Thomas More | 0 | |||
| 10/16/2021 | Cumberlands KY (6-4,6-4) | 9 | at | Thomas More | 26 | |||
| 10/23/2021 | Thomas More | 17 | at | Georgetown KY (8-2,8-2) | 27 | |||
| 10/30/2021 | Cumberland TN (3-7,3-7) | 3 | at | Thomas More | 10 | |||
| 11/6/2021 | Thomas More | 24 | at | Bethel TN (7-4,7-3) | 14 | |||
| 11/13/2021 | Pikeville (4-5,4-5) | 13 | at | Thomas More | 7 |
| vs Thomas More | vs Other Opponents | Thomas More compared to OOs | |
| Record: | 5-5 | 56-37 | |
| Points Scored: | 22.10 | 31.57 | 9.47 |
| Points Allowed: | 23.60 | 26.27 | -2.67 |
| Margin: | -1.50 | 5.30 | 6.80 |
| Total Points: | 45.70 | 57.84 | -12.14 |