| 8/28/2021 | Evangel | 24 | at | Clarke | 9 | |||
| Baker | 38 | at | Culver-Stockton | 36 | ||||
| MidAmerica Nazarene | 49 | at | Graceland | 17 | ||||
| Central Methodist | 10 | at | Grand View | 37 | ||||
| Missouri Valley | 21 | at | Peru State | 47 | ||||
| Benedictine KS | 35 | at | William Penn | 13 | ||||
| 9/4/2021 | William Penn | 21 | at | Baker | 47 | |||
| Grand View | 41 | at | Benedictine KS | 20 | ||||
| Peru State | 24 | at | Central Methodist | 27 | ||||
| Graceland | 0 | at | Evangel | 62 | ||||
| Culver-Stockton | 37 | at | MidAmerica Nazarene | 19 | ||||
| Clarke | 20 | at | Missouri Valley | 44 | ||||
| 9/11/2021 | Central Methodist | 31 | at | Clarke | 16 | |||
| Evangel | 35 | at | Culver-Stockton | 38 | ||||
| Missouri Valley | 38 | at | Graceland | 24 | ||||
| Baker | 14 | at | Grand View | 31 | ||||
| Benedictine KS | 21 | at | Peru State | 45 | ||||
| MidAmerica Nazarene | 44 | at | William Penn | 45 | ||||
| 9/17/2021 | William Penn | 14 | at | Evangel | 28 | |||
| 9/18/2021 | Peru State | 3 | at | Baker | 33 | |||
| Clarke | 0 | at | Benedictine KS | 68 | ||||
| Graceland | 0 | at | Central Methodist | 44 | ||||
| Grand View | 47 | at | MidAmerica Nazarene | 21 | ||||
| Culver-Stockton | 52 | at | Missouri Valley | 28 | ||||
| 9/25/2021 | Baker | 41 | at | Clarke | 6 | |||
| Central Methodist | 36 | at | Culver-Stockton | 44 | ||||
| Benedictine KS | 62 | at | Graceland | 7 | ||||
| Evangel | 6 | at | Grand View | 23 | ||||
| MidAmerica Nazarene | 14 | at | Peru State | 21 | ||||
| Missouri Valley | 30 | at | William Penn | 27 | ||||
| 10/2/2021 | Graceland | 7 | at | Baker | 58 | |||
| Culver-Stockton | 24 | at | Benedictine KS | 65 | ||||
| William Penn | 27 | at | Central Methodist | 28 | ||||
| Peru State | 23 | at | Evangel | 22 | ||||
| Clarke | 39 | at | MidAmerica Nazarene | 56 | ||||
| Grand View | 59 | at | Missouri Valley | 10 | ||||
| 10/16/2021 | MidAmerica Nazarene | 20 | at | Baker | 62 | |||
| Benedictine KS | 24 | at | Central Methodist | 30 | ||||
| Culver-Stockton | 50 | at | Graceland | 3 | ||||
| William Penn | 0 | at | Grand View | 38 | ||||
| Evangel | 30 | at | Missouri Valley | 23 | ||||
| Clarke | 0 | at | Peru State | 20 | ||||
| 10/23/2021 | Missouri Valley | 37 | at | Benedictine KS | 47 | |||
| Culver-Stockton | 17 | at | Clarke | 6 | ||||
| Baker | 34 | at | Evangel | 21 | ||||
| Grand View | 77 | at | Graceland | 9 | ||||
| Central Methodist | 41 | at | MidAmerica Nazarene | 24 | ||||
| Peru State | 28 | at | William Penn | 0 | ||||
| 10/30/2021 | Benedictine KS | 23 | at | Baker | 28 | |||
| Missouri Valley | 7 | at | Central Methodist | 41 | ||||
| William Penn | 28 | at | Culver-Stockton | 52 | ||||
| Clarke | 37 | at | Graceland | 14 | ||||
| Peru State | 7 | at | Grand View | 27 | ||||
| Evangel | 37 | at | MidAmerica Nazarene | 29 | ||||
| 11/6/2021 | Baker | 19 | at | Central Methodist | 21 | |||
| William Penn | 28 | at | Clarke | 17 | ||||
| Benedictine KS | 34 | at | Evangel | 0 | ||||
| Culver-Stockton | 6 | at | Grand View | 9 | ||||
| MidAmerica Nazarene | 42 | at | Missouri Valley | 35 | OT | |||
| Graceland | 7 | at | Peru State | 51 | ||||
| 11/13/2021 | MidAmerica Nazarene | 58 | at | Benedictine KS | 70 | |||
| Grand View | 31 | at | Clarke | 7 | ||||
| Peru State | 3 | at | Culver-Stockton | 10 | ||||
| Central Methodist | 17 | at | Evangel | 7 | ||||
| Baker | 45 | at | Missouri Valley | 14 | ||||
| Graceland | 6 | at | William Penn | 71 | ||||
| 11/20/2021 | Dickinson State | 13 | at | Grand View | 38 | NSAA | ||
| Central Methodist | 7 | at | Northwestern IA | 24 | @ GPAC | |||
| 11/27/2021 | Concordia MI | 16 | at | Grand View | 31 | MSFA | ||
| 12/4/2021 | Grand View | 34 | at | Lindsey Wilson | 28 | @ MSC | ||
| 12/18/2021 | Grand View | 28 | vs | Morningside | 38 | NAIA Championship - Durham NC | vs GPAC |