| 9/4/2021 | McDaniel (2-8) | 7 | at | Catholic | 40 | Cen | ||
| 9/11/2021 | Catholic | 10 | at | Randolph-Macon (9-1) | 62 | at ODC | ||
| 9/18/2021 | Endicott (8-3) | 29 | at | Catholic | 32 | CCF | ||
| 9/25/2021 | Christopher Newport (5-5) | 31 | at | Catholic | 14 | NJAC | ||
| 10/2/2021 | MIT (5-4,3-3) | 13 | at | Catholic | 23 | |||
| 10/9/2021 | Catholic | 30 | at | Worcester Polytechnic (3-7,2-4) | 7 | |||
| 10/16/2021 | Coast Guard (2-8,0-6) | 7 | at | Catholic | 30 | |||
| 10/23/2021 | Catholic | 34 | at | Merchant Marine (9-1,5-1) | 44 | |||
| 11/6/2021 | Norwich (2-8,1-5) | 14 | at | Catholic | 35 | |||
| 11/13/2021 | Catholic | 14 | at | Springfield (7-4,6-0) | 28 |
| vs Catholic | vs Other Opponents | Catholic compared to OOs | |
| Record: | 4-6 | 48-43 | |
| Points Scored: | 24.20 | 26.67 | 2.47 |
| Points Allowed: | 26.20 | 23.97 | 2.23 |
| Margin: | -2.00 | 2.70 | 4.70 |
| Total Points: | 50.40 | 50.64 | -0.24 |