| 9/4/2021 | Curry (3-6) | 7 | at | MIT | 41 | CCF | ||
| 9/11/2021 | MIT | 16 | at | Salve Regina (8-2) | 21 | at CCF | ||
| 9/25/2021 | MIT | 27 | at | Dean (2-8) | 0 | at ECFC | ||
| 10/2/2021 | MIT | 13 | at | Catholic (6-4,4-2) | 23 | |||
| 10/16/2021 | MIT | 34 | at | Merchant Marine (9-1,5-1) | 56 | |||
| 10/23/2021 | Norwich (2-8,1-5) | 37 | at | MIT | 48 | |||
| 10/30/2021 | MIT | 21 | at | Coast Guard (2-8,0-6) | 7 | |||
| 11/6/2021 | Springfield (7-4,6-0) | 17 | at | MIT | 7 | |||
| 11/13/2021 | Worcester Polytechnic (3-7,2-4) | 10 | at | MIT | 38 |
| vs MIT | vs Other Opponents | MIT compared to OOs | |
| Record: | 4-5 | 38-43 | |
| Points Scored: | 19.78 | 26.51 | 6.73 |
| Points Allowed: | 27.22 | 25.89 | 1.33 |
| Margin: | -7.44 | 0.62 | 8.06 |
| Total Points: | 47.00 | 52.40 | -5.40 |