| 9/4/2021 | LaGrange | 17 | at | Birmingham-Southern (10-2) | 42 | at SAA | ||
| 9/11/2021 | Berry (6-4) | 34 | at | LaGrange | 21 | SAA | ||
| 9/18/2021 | LaGrange | 38 | at | Southern Virginia (2-8) | 34 | at ODC | ||
| 9/25/2021 | North Carolina Wesleyan (4-6,2-4) | 26 | at | LaGrange | 21 | |||
| 10/9/2021 | LaGrange | 17 | at | Methodist (7-2,5-1) | 34 | |||
| 10/16/2021 | Brevard (6-4,4-2) | 20 | at | LaGrange | 10 | |||
| 10/23/2021 | LaGrange | 16 | at | Maryville (4-6,3-3) | 52 | |||
| 10/30/2021 | Greensboro (0-10,0-6) | 14 | at | LaGrange | 29 | |||
| 11/6/2021 | LaGrange | 22 | at | Averett (5-5) | 31 | at ODC | ||
| 11/13/2021 | Huntingdon AL (8-3,6-0) | 55 | at | LaGrange | 9 |
| vs LaGrange | vs Other Opponents | LaGrange compared to OOs | |
| Record: | 8-2 | 44-48 | |
| Points Scored: | 34.20 | 25.13 | -9.07 |
| Points Allowed: | 20.00 | 23.89 | -3.89 |
| Margin: | 14.20 | 1.24 | -12.96 |
| Total Points: | 54.20 | 49.02 | 5.18 |