| 9/4/2021 | Greensboro | 7 | at | Guilford (1-7) | 21 | at ODC | ||
| 9/18/2021 | Averett (5-5) | 48 | at | Greensboro | 2 | ODC | ||
| 9/25/2021 | Gallaudet (4-3) | 49 | at | Greensboro | 42 | ECFC | ||
| 10/2/2021 | Brevard (6-4,4-2) | 27 | at | Greensboro | 7 | |||
| 10/9/2021 | Greensboro | 0 | at | North Carolina Wesleyan (4-6,2-4) | 21 | |||
| 10/16/2021 | Greensboro | 14 | at | Southern Virginia (2-8) | 31 | at ODC | ||
| 10/23/2021 | Huntingdon AL (8-3,6-0) | 42 | at | Greensboro | 3 | |||
| 10/30/2021 | Greensboro | 14 | at | LaGrange (2-8,1-5) | 29 | |||
| 11/6/2021 | Methodist (7-2,5-1) | 40 | at | Greensboro | 14 | |||
| 11/13/2021 | Greensboro | 14 | at | Maryville (4-6,3-3) | 49 |
| vs Greensboro | vs Other Opponents | Greensboro compared to OOs | |
| Record: | 10-0 | 33-52 | |
| Points Scored: | 35.70 | 23.55 | -12.15 |
| Points Allowed: | 11.70 | 28.78 | -17.08 |
| Margin: | 24.00 | -5.23 | -29.23 |
| Total Points: | 47.40 | 52.33 | -4.93 |