| 9/4/2021 | Hanover (5-5) | 34 | at | Centre | 56 | HCA | ||
| 9/11/2021 | Centre | 40 | at | Maryville (4-6) | 21 | at USASC | ||
| 9/25/2021 | Trine (6-4) | 7 | at | Centre | 14 | MIAA | ||
| 10/2/2021 | Hendrix (3-7,3-5) | 21 | at | Centre | 42 | |||
| 10/9/2021 | Centre | 7 | at | Trinity TX (9-1,7-0) | 27 | |||
| 10/16/2021 | Birmingham-Southern (10-2,6-1) | 28 | at | Centre | 21 | |||
| 10/23/2021 | Centre | 66 | at | Millsaps (2-8,2-5) | 34 | |||
| 10/30/2021 | Rhodes (3-7,2-5) | 6 | at | Centre | 49 | |||
| 11/6/2021 | Centre | 30 | at | Sewanee (0-10,0-8) | 20 | |||
| 11/13/2021 | Centre | 49 | at | Berry (6-4,4-3) | 27 |
| vs Centre | vs Other Opponents | Centre compared to OOs | |
| Record: | 2-8 | 46-46 | |
| Points Scored: | 22.50 | 28.99 | 6.49 |
| Points Allowed: | 37.40 | 26.32 | 11.08 |
| Margin: | -14.90 | 2.67 | 17.57 |
| Total Points: | 59.90 | 55.31 | 4.59 |