| 9/4/2021 | Erskine (3-8) | 27 | at | Catawba | 37 | D2Ind | ||
| 9/11/2021 | Winston-Salem State (3-6) | 6 | at | Catawba | 28 | CIAA | ||
| 9/18/2021 | Barton (6-5) | 10 | at | Catawba | 17 | D2Ind | ||
| 9/25/2021 | Catawba | at | Wingate (7-3,5-2) | Cancelled | ||||
| 10/2/2021 | Limestone (0-9,0-7) | at | Catawba | Canceled | ||||
| 10/9/2021 | Carson-Newman (1-9,1-7) | 27 | at | Catawba | 33 | |||
| 10/16/2021 | Catawba | 7 | at | Newberry (10-3,7-1) | 14 | |||
| 10/23/2021 | Catawba | 14 | at | Mars Hill (8-3,6-2) | 31 | |||
| 10/30/2021 | Tusculum (5-6,3-5) | 28 | at | Catawba | 31 | |||
| 11/6/2021 | Virginia-Wise (5-6,4-4) | 30 | at | Catawba | 7 | |||
| 11/13/2021 | Catawba | 3 | at | Lenoir-Rhyne (8-3,6-2) | 56 |
| vs Catawba | vs Other Opponents | Catawba compared to OOs | |
| Record: | 4-5 | 52-56 | |
| Points Scored: | 25.44 | 26.34 | 0.90 |
| Points Allowed: | 19.67 | 26.22 | -6.55 |
| Margin: | 5.77 | 0.12 | -5.65 |
| Total Points: | 45.11 | 52.56 | -7.45 |