| 9/2/2021 | Minnesota State-Moorhead (5-6,5-6) | 33 | at | Southwest Minnesota State | 21 | | | |
| 9/11/2021 | Southwest Minnesota State | 13 | at | Northern State (7-4,7-4) | 30 | | | |
| 9/18/2021 | Mary (4-7,4-7) | 45 | at | Southwest Minnesota State | 23 | | | |
| 9/25/2021 | Southwest Minnesota State | 34 | at | Concordia-St Paul (1-10,1-10) | 24 | | | |
| 10/2/2021 | Southwest Minnesota State | 20 | at | Upper Iowa (1-10,1-10) | 14 | | | |
| 10/9/2021 | Sioux Falls (8-3,8-3) | 35 | at | Southwest Minnesota State | 7 | | | |
| 10/16/2021 | Southwest Minnesota State | 14 | at | Winona State (7-4,7-4) | 26 | | | |
| 10/23/2021 | Wayne State NE (7-4,7-4) | 38 | at | Southwest Minnesota State | 16 | | | |
| 10/30/2021 | Southwest Minnesota State | 14 | at | Bemidji State (10-3,10-2) | 48 | | | |
| 11/6/2021 | Minnesota State-Mankato (6-5,6-5) | 52 | at | Southwest Minnesota State | 0 | | | |
| 11/13/2021 | Southwest Minnesota State | 0 | at | Augustana SD (9-3,9-3) | 55 | | | |