| 9/2/2021 | Mary (4-7,4-7) | 27 | at | Wayne State NE | 34 | | | |
| 9/11/2021 | Wayne State NE | 28 | at | Bemidji State (10-3,10-2) | 38 | | | |
| 9/18/2021 | Minot State (2-9,2-9) | 0 | at | Wayne State NE | 48 | | | |
| 9/25/2021 | Wayne State NE | 31 | at | Minnesota-Duluth (9-3,9-2) | 28 | | | |
| 10/2/2021 | Winona State (7-4,7-4) | 21 | at | Wayne State NE | 38 | | | |
| 10/9/2021 | Wayne State NE | 35 | at | Minnesota State-Mankato (6-5,6-5) | 24 | | | |
| 10/16/2021 | Augustana SD (9-3,9-3) | 32 | at | Wayne State NE | 24 | | | |
| 10/23/2021 | Wayne State NE | 38 | at | Southwest Minnesota State (2-9,2-9) | 16 | | | |
| 10/30/2021 | Wayne State NE | 41 | at | Upper Iowa (1-10,1-10) | 42 | OT | | |
| 11/6/2021 | Sioux Falls (8-3,8-3) | 38 | at | Wayne State NE | 17 | | | |
| 11/13/2021 | Wayne State NE | 24 | at | Minnesota State-Moorhead (5-6,5-6) | 21 | | | |