| 9/2/2021 | Northern State | 34 | at | Minnesota State-Mankato (6-5,6-5) | 40 | OT | | |
| 9/11/2021 | Southwest Minnesota State (2-9,2-9) | 13 | at | Northern State | 30 | | | |
| 9/18/2021 | Northern State | 40 | at | Upper Iowa (1-10,1-10) | 22 | | | |
| 9/25/2021 | Sioux Falls (8-3,8-3) | 10 | at | Northern State | 41 | | | |
| 10/2/2021 | Mary (4-7,4-7) | 49 | at | Northern State | 42 | | | |
| 10/9/2021 | Northern State | 52 | at | Winona State (7-4,7-4) | 49 | | | |
| 10/16/2021 | Minot State (2-9,2-9) | 35 | at | Northern State | 36 | | | |
| 10/23/2021 | Northern State | 38 | at | Concordia-St Paul (1-10,1-10) | 17 | | | |
| 10/30/2021 | Northern State | 33 | at | Minnesota State-Moorhead (5-6,5-6) | 27 | | | |
| 11/6/2021 | Bemidji State (10-3,10-2) | 36 | at | Northern State | 34 | | | |
| 11/13/2021 | Northern State | 35 | at | Minnesota-Duluth (9-3,9-2) | 49 | | | |