| 9/4/2021 | Saint Anselm (3-6) | 23 | at | Merrimack | 55 | NE10 (D2) | ||
| 9/11/2021 | Merrimack | 35 | at | Holy Cross (10-3) | 21 | at Pat | ||
| 9/18/2021 | Merrimack | 26 | at | Maine (6-5) | 31 | at CAAF | ||
| 9/25/2021 | Merrimack | 47 | at | Delaware State (5-6) | 10 | at MEAC | ||
| 10/2/2021 | Duquesne (7-3,5-2) | 37 | at | Merrimack | 14 | |||
| 10/9/2021 | Merrimack | 10 | at | Sacred Heart (8-4,6-1) | 20 | |||
| 10/16/2021 | Merrimack | 43 | at | LIU (2-8,2-5) | 5 | |||
| 10/30/2021 | Central Conn (4-7,4-3) | 49 | at | Merrimack | 21 | |||
| 11/6/2021 | Merrimack | 35 | at | Wagner (0-11,0-7) | 26 | |||
| 11/13/2021 | Merrimack | 6 | at | St Francis PA (5-6,4-3) | 22 | |||
| 11/20/2021 | Bryant (7-4,5-2) | 58 | at | Merrimack | 14 |
| vs Merrimack | vs Other Opponents | Merrimack compared to OOs | |
| Record: | 6-5 | 51-58 | |
| Points Scored: | 27.45 | 22.94 | -4.51 |
| Points Allowed: | 27.82 | 25.92 | 1.90 |
| Margin: | -0.37 | -2.98 | -2.61 |
| Total Points: | 55.27 | 48.86 | 6.41 |