| 9/4/2021 | Saint Anselm | 23 | at | Merrimack (5-6) | 55 | at NE | ||
| 9/17/2021 | Saint Anselm | 31 | at | Southern Connecticut (4-6,3-6) | 34 | |||
| 9/25/2021 | Franklin Pierce (0-10,0-9) | 7 | at | Saint Anselm | 42 | |||
| 10/2/2021 | Bentley (9-2,8-2) | 34 | at | Saint Anselm | 21 | |||
| 10/9/2021 | Saint Anselm | 7 | at | New Haven (10-2,10-0) | 56 | |||
| 10/16/2021 | Saint Anselm | 22 | at | Stonehill (8-2,7-2) | 31 | |||
| 10/23/2021 | Pace (2-8,2-7) | 16 | at | Saint Anselm | 24 | |||
| 10/30/2021 | American Int'l (4-6,3-6) | 16 | at | Saint Anselm | 21 | |||
| 11/6/2021 | Saint Anselm | 35 | at | Assumption (5-5,5-4) | 44 | |||
| 11/13/2021 | Saint Anselm | at | Bluefield St WV (3-3) | Cancelled | at D2Ind |
| vs Saint Anselm | vs Other Opponents | Saint Anselm compared to OOs | |
| Record: | 6-3 | 44-47 | |
| Points Scored: | 32.56 | 23.51 | -9.05 |
| Points Allowed: | 25.11 | 24.33 | 0.78 |
| Margin: | 7.45 | -0.82 | -8.27 |
| Total Points: | 57.67 | 47.84 | 9.83 |