| 9/3/2021 | Southern Connecticut (4-6) | 28 | at | Central Conn | 21 | NE10 (D2) | ||
| 9/11/2021 | Central Conn | 21 | at | Wagner (0-11,0-7) | 19 | |||
| 9/18/2021 | Southeastern Louisiana (9-4) | 56 | at | Central Conn | 10 | SLC | ||
| 9/25/2021 | Central Conn | 0 | at | Miami-Florida (7-5) | 69 | at ACC | ||
| 10/9/2021 | Columbia (7-3) | 22 | at | Central Conn | 20 | Ivy | ||
| 10/16/2021 | Central Conn | 17 | at | Sacred Heart (8-4,6-1) | 27 | |||
| 10/23/2021 | LIU (2-8,2-5) | 30 | at | Central Conn | 13 | |||
| 10/30/2021 | Central Conn | 49 | at | Merrimack (5-6,2-5) | 21 | |||
| 11/6/2021 | Bryant (7-4,5-2) | 15 | at | Central Conn | 30 | |||
| 11/13/2021 | Central Conn | 27 | at | Duquesne (7-3,5-2) | 31 | |||
| 11/20/2021 | St Francis PA (5-6,4-3) | 21 | at | Central Conn | 24 |
| vs Central Conn | vs Other Opponents | Central Conn compared to OOs | |
| Record: | 7-4 | 54-56 | |
| Points Scored: | 30.82 | 25.50 | -5.32 |
| Points Allowed: | 21.09 | 27.64 | -6.55 |
| Margin: | 9.73 | -2.14 | -11.87 |
| Total Points: | 51.91 | 53.14 | -1.23 |