| 9/4/2021 | Ashland | 35 | at | Notre Dame OH (11-2) | 42 | OT | at MtnE | |
| 9/11/2021 | Ferris State (14-0) | 45 | at | Ashland | 19 | GLIAC | ||
| 9/25/2021 | Quincy (4-7) | 23 | at | Ashland | 63 | GLV | ||
| 9/30/2021 | Ashland | 35 | at | Walsh (2-9,1-6) | 10 | |||
| 10/9/2021 | Ohio Dominican (7-4,4-3) | 34 | at | Ashland | 24 | |||
| 10/16/2021 | Ashland | 21 | at | Tiffin (8-3,5-2) | 27 | |||
| 10/23/2021 | Lake Erie (5-6,2-5) | 41 | at | Ashland | 42 | |||
| 10/30/2021 | Hillsdale (6-6,5-2) | 17 | at | Ashland | 28 | |||
| 11/6/2021 | Ashland | 17 | at | Findlay (8-4,6-1) | 20 | |||
| 11/13/2021 | Ashland | 17 | at | Kentucky Wesleyan (3-8,1-6) | 0 |
| vs Ashland | vs Other Opponents | Ashland compared to OOs | |
| Record: | 5-5 | 63-44 | |
| Points Scored: | 25.90 | 30.50 | 4.60 |
| Points Allowed: | 30.10 | 24.61 | 5.49 |
| Margin: | -4.20 | 5.89 | 10.09 |
| Total Points: | 56.00 | 55.11 | 0.89 |