| 9/4/2021 | Allen (3-5,1-4) | 12 | at | Benedict | 45 | |||
| 9/9/2021 | Edward Waters (4-7,3-7) | 3 | at | Benedict | 44 | |||
| 9/18/2021 | Benedict | 34 | at | Savannah State (8-2,6-1) | 41 | |||
| 9/25/2021 | Benedict | 28 | at | Kentucky State (7-4,6-2) | 34 | |||
| 10/2/2021 | Fort Valley State (5-5,5-4) | 24 | at | Benedict | 14 | |||
| 10/9/2021 | Benedict | 24 | at | Miles (6-5,6-3) | 21 | |||
| 10/16/2021 | Albany State GA (10-2,8-0) | 28 | at | Benedict | 6 | |||
| 10/23/2021 | Morehouse (4-6,4-4) | 20 | at | Benedict | 5 | |||
| 10/30/2021 | Benedict | 24 | at | Clark Atlanta (2-8,1-7) | 21 | |||
| 11/6/2021 | Lane (6-4,5-3) | 30 | at | Benedict | 34 |
| vs Benedict | vs Other Opponents | Benedict compared to OOs | |
| Record: | 5-5 | 50-43 | |
| Points Scored: | 23.40 | 25.83 | 2.43 |
| Points Allowed: | 25.80 | 23.94 | 1.86 |
| Margin: | -2.40 | 1.89 | 4.29 |
| Total Points: | 49.20 | 49.77 | -0.57 |