| 9/2/2021 | Western Oregon | 3 | at | Colorado Mines | 42 | @ RMAC | ||
| Central Washington | 66 | at | Eastern New Mexico | 24 | @ LSC | |||
| 9/4/2021 | Simon Fraser | 0 | at | Idaho | 68 | @ BSky (1AA) | ||
| 9/11/2021 | Central Washington | 14 | at | Eastern Washington | 63 | @ BSky (1AA) | ||
| Simon Fraser | 20 | at | Linfield | 56 | @ NWC (D3) | |||
| Western Oregon | 10 | at | Texas A&M-Kingsville | 24 | @ LSC | |||
| 9/18/2021 | Western Oregon | 7 | at | Portland State | 21 | @ BSky (1AA) | ||
| Central Washington | 36 | at | Simon Fraser | 14 | ||||
| 9/25/2021 | Angelo State | 14 | at | Central Washington | 9 | LSC | ||
| Western Oregon | 24 | at | Simon Fraser | 7 | ||||
| 10/2/2021 | Midwestern State | 20 | at | Central Washington | 30 | LSC | ||
| Texas-Permian Basin | at | Simon Fraser | Canceled | LSC | ||||
| West Texas A&M | 38 | at | Western Oregon | 41 | LSC | |||
| 10/9/2021 | Central Washington | 45 | at | Western Oregon | 14 | |||
| 10/16/2021 | Simon Fraser | 30 | at | Montana State-Northern | 3 | @ Front (NAIA) | ||
| 10/23/2021 | Simon Fraser | 10 | at | Angelo State | 51 | @ LSC | ||
| Western Oregon | 21 | at | Central Washington | 53 | ||||
| 10/30/2021 | Lincoln CA | 0 | at | Central Washington | 92 | None (Unk?) | ||
| Simon Fraser | 3 | at | Western Oregon | 42 | ||||
| 11/6/2021 | Western Oregon | 7 | at | Chadron State | 45 | @ RMAC | ||
| Central Washington | 54 | at | Western New Mexico | 29 | @ LSC | |||
| 11/13/2021 | Simon Fraser | 0 | at | Central Washington | 70 | |||
| Lincoln CA | 16 | at | Western Oregon | 55 | None (Unk?) | |||
| 11/20/2021 | Central Washington | 21 | at | Northwest Missouri State | 50 | @ MAIAA |