| 9/4/2021 | Portland State | 35 | at | Hawaii (6-7) | 49 | at MW | ||
| 9/11/2021 | Portland State | 24 | at | Washington State (7-6) | 44 | at P12 | ||
| 9/18/2021 | Western Oregon (4-6) | 7 | at | Portland State | 21 | GNWAC (D2) | ||
| 9/25/2021 | Montana State (12-3,7-1) | 30 | at | Portland State | 17 | |||
| 10/2/2021 | Portland State | 20 | at | Southern Utah (1-10,0-8) | 13 | |||
| 10/9/2021 | Portland State | 35 | at | Idaho (4-7,3-5) | 42 | |||
| 10/16/2021 | Idaho State (1-10,1-7) | 10 | at | Portland State | 31 | |||
| 10/30/2021 | Cal Poly (2-9,1-7) | 21 | at | Portland State | 42 | |||
| 11/6/2021 | Portland State | 30 | at | Weber State (6-5,5-3) | 18 | |||
| 11/13/2021 | Portland State | 20 | at | Sacramento State (9-3,8-0) | 49 | |||
| 11/20/2021 | Eastern Washington (10-3,6-3) | 42 | at | Portland State | 28 |
| vs Portland State | vs Other Opponents | Portland State compared to OOs | |
| Record: | 6-5 | 56-64 | |
| Points Scored: | 29.55 | 26.42 | -3.13 |
| Points Allowed: | 27.55 | 27.76 | -0.21 |
| Margin: | 2.00 | -1.34 | -3.34 |
| Total Points: | 57.10 | 54.18 | 2.92 |